New dosing guidelines for the treatment of paracetamol overdose and toxicity

30 Jan 2019 | Medication Safety

The National Poisons Centre has issued new dosing guidance for acetylcysteine for the treatment of paracetamol overdose and toxicity.

A 2-bag dosing regimen is now recommended:

  Dose acetylcysteine:
1. First bag 200mg/kg IV over 4 hours
2. Second bag 100mg/kg IV over 16 hours

Current evidence suggests a modified two-bag dosing regimen is associated with a reduction in adverse effects associated with acetylcysteine administration. As the new dosing recommendations are simpler than the traditional ones, there is a reduced risk of administration errors.

Download the treatment guidelines below.

Last updated 30/01/2019