The National Poisons Centre has issued new dosing guidance for acetylcysteine for the treatment of paracetamol overdose and toxicity.
A 2-bag dosing regimen is now recommended:
|1. First bag||200mg/kg IV over 4 hours|
|2. Second bag||100mg/kg IV over 16 hours|
Current evidence suggests a modified two-bag dosing regimen is associated with a reduction in adverse effects associated with acetylcysteine administration. As the new dosing recommendations are simpler than the traditional ones, there is a reduced risk of administration errors.
Download the treatment guidelines below.