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The opioids domain of the Atlas of Healthcare Variation gives an overview on the use of opioids, by district health board (DHB), to identify areas of wide variation.
Update with 2016 data
(Updated December 2017)
The number of people dispensed a strong opioid continues to increase
- A ‘strong’ opioid is one classed as step 3 of the World Health Organization (WHO) analgesic ladder. In New Zealand the following strong opioids are subsidised: fentanyl, methadone, morphine, oxycodone and pethidine.
- Excluding people receiving methadone for opioid substitution treatment, in 2016, an average of 16.7 per 1,000 people in New Zealand received a strong opioid. There was a two-fold variation between DHBs.
- People identifying as European/Other ethnicity were dispensed a strong opioid 2–5 times more than other ethnic groups.
- Use increased significantly with each age group; on average, 11 percent of people aged 80+ received a strong opioid in 2016.
- Women were dispensed significantly more strong opioids than men.
- Of the people receiving a strong opioid, 12.5 percent took the opioid for six or more weeks. Rates have remained steady since 2012.
Weak opioid use increases with age
- A ‘weak’ opioid is classed as step 2 of the WHO analgesic ladder. In New Zealand the following weak opioids are subsidised: tramadol, codeine and dihydrocodeine. A technical error meant that one chemical was not included in the previous extract. The result of including this is an increase in the rate of weak opioid dispensing from 66 per 1,000 population to 103.5 per 1,000. Paracetamol with codeine was excluded as it contains a comparatively low dose of codeine.
- In 2016, an average of 103.5 per 1,000 people in New Zealand received a weak opioid. Nationally, tramadol was dispensed to fewer people than codeine or dihydrocodeine – 50.8 per 1,000 compared with 64.3 per 1,000. However, this varied across the country.
- People identifying as European/Other ethnicity received significantly more weak opioids, while Asian peoples received significantly fewer.
- Use increased significantly with age; on average nearly 20 percent of people aged 80+ received a weak opioid in 2016.
- As with strong opioids, women were dispensed significantly more weak opioids than men.
Morphine use has increased since 2011
- In 2016, an average of 11.2 per 1,000 people received morphine. Use varied two-fold between DHBs.
- Of those dispensed a strong opioid in 2016, two-thirds received morphine.
- The number of people dispensed morphine has significantly increased by 19,000 people since 2011, from 7.5 to 11 per 1,000 people in 2016.
- Of every 10 people given morphine, 1.2 took it for six or more weeks.
Oxycodone use has not changed since 2015
- In 2016, an average of 5.4 per 1,000 people received oxycodone.
- Use varied more than three-fold between DHBs.
- Of every 10 people given oxycodone, 1.2 took it for six or more weeks.
Rates of fentanyl use are increasing but vary widely
- In 2016, an average of 1.8 per 1,000 people received fentanyl. This was a significant increase from 2011 (0.8 per 1,000). Use varied over 12-fold between DHBs.
- Of those given fentanyl, 23 percent took it for six or more weeks.
Almost half of those dispensed a strong opioid had a public hospital ‘trigger event’
- Of every 10 people dispensed a strong opioid, 4.7 attended a public hospital as an inpatient or outpatient in the week prior.
- Younger people were more likely to have a public hospital event (7/10) prior to dispensing of a strong opioid compared with older – 3.7/10 of those aged 80+.
Use of medication by site of residence | 65 and over (2016)
Further analysis was done comparing dispensing rates of three strong opioids according to where people live. Two groups were created – those aged 65 and over living in the community and those aged 65 and over living in a rest home. People in a rest home receiving a higher level of care, such as rest-home hospital, dementia or psycho-geriatric, were excluded from this analysis to make the groups more comparable.
As the figure below shows, fentanyl and morphine use are increasing faster in those living in a rest home than in those living in the community. Oxycodone use is reducing at a similar rate in both rest homes and the community.
The Institute for Healthcare Improvement (IHI) classes opioids as one of four groups of medicines (along with anticoagulants, insulin and sedatives) that can cause harm to patients, even when used as intended.
Opioid analgesia is the primary intervention for managing pain in hospital patients. Opioids are also considered effective treatment for severe pain in palliative care. In the non-specialist setting, the National Institute for Health and Care Excellence (NICE) recommends opioids should not be used for neuropathic pain without specialist assessment. A 2013 review noted increases in both opioid use for back pain and other chronic musculoskeletal pain conditions, and in prescription opioid addiction and fatal overdose.
Despite the increasing use of chronic opioid therapy, there is limited evidence that opioids are effective for treating chronic non-cancer pain in the long term. A 2013 Cochrane review concluded that long-term use of opioids should be undertaken with extreme caution and should consider the potential for serious adverse effects and complications. Harms associated with opioid therapy include opioid tolerance, opioid-induced hyperalgesia, iatrogenic addiction and dependency, drug diversion and aberrant drug-related behaviours. In addition, a strong relationship between severe dependence on opioids and other substance use and mental health disorders has been observed.
It is recommended that health practitioners considering prescribing opioids for chronic non-malignant pain carefully undertake a benefit-to-harm evaluation to ensure opioid therapy is the best option. The evaluation should include taking a history, undertaking a physical examination and performing a full diagnosis before starting opioid therapy. Evaluation should be ongoing for the duration of the therapy.
Data sources and method
Data for this Atlas domain was drawn from the Pharmaceutical Collection, which contains claim and payment information from community pharmacists for subsidised dispensing. This collection does not allow for analysis of patients’ condition or the effectiveness of dose provided. This means it was not possible to assess the appropriateness or otherwise of prescribing. Unsubsidised dispensing is not included in this analysis; nor does it indicate if people took the medicine.
Note this analysis focuses on the number of people dispensed opioids, not on the number of prescriptions of these medicines. We have used this approach because interpreting what the number of dispensed prescriptions might mean is complicated by differences in prescribing frequency, formulation and dose, and if the medicine is to be taken ‘as needed’ or at regular times. We recommend further local analysis on the people receiving these medicines that accounts for these factors and the person’s clinical condition.
What questions might these data prompt?
- Why do some DHBs have consistently lower or higher rates than the national mean?
- How do DHBs with similar populations compare?
- What are your DHB’s trends for opioid prescribing in aged residential care?
- What is driving the prescribing of morphine and fentanyl in the elderly?
- What is the effect of a DHB’s access to specialist pain services on the use of opioids?
- What is the effect of access to palliative care services?
- What impact might access to non-pharmacologic pain management have on these rates?
- What tools and skills do primary care providers have to manage chronic non-cancer pain?
- Why are there marked ethnic differences in the use of opioids? Is it the result of higher use in older people or might it reflect other differences, such as different cultural expressions of pain and different ways of coping with pain?
- What other combinations of medicines are people receiving strong opioids for six or more weeks also receiving? Additional analysis showed almost half of those on strong opioids (4.6/10) received a benzodiazepine in the same period.
- What is the extent of polypharmacy in older patients who are using opioids?
- How does the falls rate of older people in your DHB who are using opioids compare with the rate in those who are not?
- What regular pain management medicines are used by older people who have had a fall?
Find My Patients query and clinical audit template
Find My Patients allows you to run three different queries using your patient management system (PMS) to identify patients who received a strong opioid:
- for at least a month and
- have diagnosed chronic obstructive pulmonary disease (COPD) (strong opioids are either contraindicated or have a caution) and
- have no co-prescribed stimulant laxative to deal with the common side effect of constipation.
You can also use the query as part of a clinical audit. GPs who complete the audit are entitled to Maintenance of Professional Standards (MOPS) credits from the Royal New Zealand College of General Practitioners (RNZCGP). Download information and instructions for using the opioids query and clinical audit.
- bpacnz. 2014. Identifying and managing addiction to opioids. Best Practice Journal 64. URL: www.bpac.org.nz/BPJ/2014/October/opioid-addiction.aspx.
- bpacnz. 2014. Helping patients cope with chronic non-malignant pain: it’s not about opioids. Best Practice Journal 63. URL: www.bpac.org.nz/BPJ/2014/September/chronicpain.aspx.
- bpacnz. 2014. Upfront: “A disaster in the making”: it’s time to take action against misuse of oxycodone. Best Practice Journal 61. URL: www.bpac.org.nz/BPJ/2014/June/upfront.aspx.
- bpacnz. 2012. Strong opioids for pain management in adults in palliative care. Best Practice Journal 49. URL: www.bpac.org.nz/bpj/2012/december/opioids.aspx.
- bpacnz. 2016. Oxycodone update. BPAC reports. URL: www.bpac.org.nz/Report/2016/February/oxycodone.aspx.
- Health Quality & Safety Commission. 2016. Making strong opioids safer for patients (factsheet). Wellington: Health Quality & Safety Commission. URL: www.open.hqsc.govt.nz/medication/publications-and-resources/publication/2225.
- The Royal Australasian College of Physicians. 2009. Prescription Opioid Policy: Improving management of chronic non-malignant pain and prevention of problems associated with prescription opioid use. Sydney: The Royal Australasian College of Physicians. URL: www.ranzcp.org/Files/Resources/College_Statements/Practice_Guidelines/Chronic-non-malignant-pain-2009.aspx.
- Roxburgh A, Bruno R, Larance B et al. 2011. Prescription of opioid analgesics and related harms in Australia. Med J Aust 195(5): 280–4. URL: www.mja.com.au/journal/2011/195/5/prescription-opioid-analgesics-and-related-harms-australia.
- Scottish Intercollegiate Guidelines Network (SIGN). Management of chronic pain. Edinburgh: SIGN. (SIGN publication no. 136). [December 2013]. URL: www.sign.ac.uk.
- bpacnz. 2012. Strong opioids for pain management in adults in palliative care. Best Practice Journal 49. URL: www.bpac.org.nz/bpj/2012/december/docs/bpj_49_opioids_pages_8-17.pdf.
- NICE. 2013. Do not use morphine to treat neuropathic pain in non-specialist settings, unless advised by a specialist to do so. URL: www.nice.org.uk/donotdo/do-not-use-morphine-to-treat-neuropathic-pain-in-nonspecialist-settingsunless-advised-by-a-specialist-to-do-so (accessed 20 June 2016).
- Korff M. 2013. Long-term Use of Opioids for Complex Chronic Pain. Best Pract Res Clin Rheumatol 27(5): 663–72.
- Chaparro LE, Furlan AD, Deshpande A, Mailis-Gagnon A, Atlas S, Turk DC. Opioids compared to placebo or other treatments for chronic low-back pain. Cochrane Database of Systematic Reviews 2013, Issue 8. Art. No: CD004959. DOI: 10.1002/14651858.CD004959.pub4.
- Sullivan MD , Von Korff M , Banta-Green C , et al. 2010. Problems and concerns of patients receiving chronic opioid therapy for chronic non-cancer pain. J Pain 149(2): 345–53.
- The Royal Australasian College of Physicians. 2009. Prescription Opioid Policy: Improving management of chronic non-malignant pain and prevention of problems associated with prescription opioid use. Sydney The Royal Australasian College of Physicians.
- Chou R, Fanciullo GJ, Fine PG et al. 2009. Clinical guidelines for the use of chronic opioid therapy in chronic noncancer pain. J Pain 10(2): 113–30. DOI: 10.1016/j.jpain.2008.10.00.